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The World in Medicine
October 13, 1999

Leptin Link to Hypertension

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JAMA. 1999;282(14):1322. doi:10.1001/jama.282.14.1322-JWM90008-2-1

Researchers in Japan say they have demonstrated for the first time a direct link between blood levels of the hormone leptin and hypertension.

The researchers, from Sapporo Medical University, had shown earlier that blood levels of leptin, which is believed to help regulate body weight, were higher in hypertensive people of normal weight than in nonhypertensive individuals of normal weight. Their latest study analyzed blood leptin levels, blood pressure, and insulin sensitivity in 133 men and 263 women under age 65 who did not have diabetes or a history of drug treatment for hypertension.