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Medical News & Perspectives
December 15, 1999

Pesticide Study Aids Parkinson Research

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JAMA. 1999;282(23):2200. doi:10.1001/jama.282.23.2200-JMN1215-4-1

Seattle—Researchers are developing new animal models of pathogenesis to gain greater insight into the underlying mechanisms of chronic neurodegeneration and to test new drug treatments for Parkinson disease (PD).

One such model, presented by J. Timothy Greenamyre, MD, PhD, of Emory University, at a conference on the Etiology, Pathogenesis, and Treatment of Parkinson's Disease and Other Movement Disorders, held here in October, appears to reproduce the neurochemical, neuropathological, and behavioral features of the disease through chronically exposing laboratory rats to the pesticide rotenone.