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Medical News & Perspectives
July 21, 1999

Safety of Antidepressant Use in Pregnant and Nursing Women

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JAMA. 1999;282(3):222-223. doi:10.1001/jama.282.3.222-JMN0721-2-1

Washington—New research may help physicians who treat depressed pregnant or nursing women better assess the benefits and risks of drug and nondrug therapies for both mother and child.

Selective serotonin reuptake inhibitors (SSRIs) commonly used as antidepressants generally demonstrate incomplete placental passage, with low or undetectable amounts in the umbilical cord at delivery, said Zachary Stowe, MD, of Emory University School of Medicine, Atlanta. Stowe spoke at one of several sessions on depression in pregnant and nursing women at the annual meeting of the American Psychiatric Association (APA) here in May.