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Quick Uptakes
July 28, 1999

Gene Influences Fractures

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JAMA. 1999;282(4):317. doi:10.1001/jama.282.4.317-JQU90005-3-1

A genetic trait associated with Alzheimer disease has been linked to an increased risk of osteoporotic fractures.

In a new study, researchers at the University of Pittsburgh and the University of California at San Francisco reported that older women with a form of the gene for apolipoprotein E (APOE) have a substantially increased risk of hip and wrist fractures. The researchers followed 1750 women aged 65 years and older for 7 years. They evaluated bone mineral density, APOE gene alleles, cognitive function, and the occurrence of wrist and hip fractures and falls in the study participants.

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