[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Citations 0
Quick Uptakes
August 25, 1999

Apoptotic Pathway

Author Affiliations

Copyright 1999 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1999American Medical Association

JAMA. 1999;282(8):723. doi:10.1001/jama.282.8.723-JQU90006-3-1

Researchers at the University of Kentucky College of Medicine have identified a series of molecular signals that lead to apoptosis and further neurologic damage during the initial weeks following a spinal cord injury.

The study, published this month in Nature Medicine, shows that mitochondria of neurons damaged in spinal cord injuries release the protein cytochrome c, which causes two other proteins, apaf-1 and procaspase-9, to bind. The binding process activates the caspase-3 enzyme, which cleaves several other proteins, resulting in DNA fragmentation and destruction of the cellular structure. These signals eventually reach and trigger apoptosis in oligodendroglia cells that form myelin in the central nervous system.