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Medical News & Perspectives
April 19, 2000

Japanese Develop Early Test for Lung Cancer Metastases

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JAMA. 2000;283(15):1948-1949. doi:10.1001/jama.283.15.1948-JMN0419-3-1

Tokyo—Working with investigators in the thoracic surgery department at Keio University School of Medicine, investigators here at the Central Research Laboratory of Hitachi Ltd and at the Hitachi Chemical Research Center in Irvine, Calif, have developed a method to detect the early spread of lung cancer using genetic analysis of cancer cells carried in the bloodstream.

The collaborating teams said they analyzed 121 specific genes (of 10,000 known to be expressed in lung cancer) in biopsied tissue from patients with the disease. In experiments using just six of the 121 genes, they have detected early metastasis in tissue from patients having various stages of the disease, said Masato Mitsuhashi, MD, PhD, who heads the team working in Irvine.