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Health Agencies Update
November 15, 2000

Hypertension and Kidney Disease

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JAMA. 2000;284(19):2445. doi:10.1001/jama.284.19.2445-JHA00011-3-1

The NIH called an early halt last month to one arm of an ongoing trial testing the ability of three drugs to postpone hypertension-related kidney failure in black persons after learning that one of the drugs is clearly less effective.

The trial, the African American Study of Kidney Disease and Hypertension (AASK), enrolled 1094 African Americans at 21 centers. One segment of the study compared the angiotensin-converting enzyme (ACE) inhibitor ramipril, the β-blocker metoprolol, and the calcium channel blocker (CCB) amlodipine in patients with comparable blood pressures who already had a sign of early kidney damage—at least 1 g of protein in a 24-hour urine sample.