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August 26, 2009

Prevalence of Breast Carcinoma In Situ in the United States

JAMA. 2009;302(8):846-848. doi:10.1001/jama.2009.1211

To the Editor: Breast carcinoma in situ (BCIS) comprises 20% of new breast cancer diagnoses, with 2 predominant histologic forms: ductal (DCIS) and lobular (LCIS).1 Women with DCIS often undergo treatment similar to that of women with localized invasive cancer and experience similar reductions in quality of life.2 Women diagnosed with either DCIS or LCIS are approximately 4 times more likely to develop invasive breast cancer compared with the general population.3 The Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute reports that there were 2.5 million survivors of invasive breast cancer alive in the United States in 2005,1 but we are aware of no published estimates of BCIS prevalence.

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