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July 10, 2002

LupusDubois' Lupus Erythematosus

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Copyright 2002 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2002American Medical Association

JAMA. 2002;288(2):251-252. doi:10.1001/jama.288.2.251-JBK0710-3-1

The title of the book is a tribute, perhaps inadvertent, perhaps intended, to Edmund L. Dubois (1923-1985), for it really is his lupus. Systemic lupus erythematosus was not mentioned in early rheumatology texts, and even as late as 1948 was absent or at best squeezed into a few pages.1 Dermatologists had known of its skin manifestations since von Hebra's description in the mid-19th century, which was further enhanced by his son-in-law and student, Moriz Kaposi (born Kohn, but he changed his name while at the University of Vienna to avoid confusion with another Moriz Kohn in his class), and Cazenave and Osler also advanced the concept. Systemic lupus was included among the collagen diseases by Klemperer, Pollack, and Baehr in 1942, and thus introduced to rheumatology. The description of the LE cell by Hargraves later in that decade added science to clinical description, as corticosteroids added effective treatment.

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