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November 27, 2002

Estrogen Replacement Therapy and Risk of Ovarian Cancer in Postmenopausal Women

Author Affiliations

Stephen J.LurieMD, PhD, Senior Editor


Not Available

JAMA. 2002;288(20):2538. doi:10.1001/jama.288.20.2538-JLT1127-1-2

To the Editor: Dr Lacey and colleagues1 found a significantly increased risk of ovarian cancer in women who used unopposed ERT, but not ERT with progestins. We are concerned that the sample was atypical in that most had a history of suspicious breast lumps. Eighty-four percent of the person-years on which the relative risk estimates were calculated were derived from women who were recommended to have surgery or had surgery for breast lumps.