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December 11, 2002

Antibiotic ResistanceThe Antibiotic Paradox: How the Misuse of Antibiotics Destroys Their Curative Powers

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Copyright 2002 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2002American Medical Association

JAMA. 2002;288(22):2898-2899. doi:10.1001/jama.288.22.2898-JBK1211-4-1

It has been 10 years since I reviewed the first edition of The Antibiotic Paradox, by Stuart B. Levy, MD, which was then subtitled How Miracle Drugs Are Destroying the Miracle. It was a timely book, cautionary and prophetic. Levy's history of the development of antibiotics, presentation of the mechanisms of resistance and its proliferation, and discussion of the motivation for the overuse of antibiotics remain as valid today as a decade ago.

The updated edition, newly subtitled, brings the reader up-to-date on the resistance problem and steps that the public, pharmaceutical industry, and various health care organizations are taking to control it. Much of the text and illustrations remain unchanged. However, each chapter has been revised and made current, and references have been added. The volume has gained 74 pages, including one new chapter, "The Antibacterial Craze."

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