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October 21, 2009

Corticosteroid Therapy for Severe Sepsis and Septic Shock—Reply

JAMA. 2009;302(15):1643-1645. doi:10.1001/jama.2009.1482

In Reply: Dr Minneci and colleagues suggest that potential publication bias may have influenced the results of our meta-analysis. Testing the asymmetry of the funnel plot (Figure) as proposed by Egger1 suggests significant asymmetry (P = .01). However, because of mathematical links between the log odds ratio and its standard error, the Egger method may produce a false-positive result.2