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The World in Medicine
December 16, 2009

Clue to Arthritis Spread

JAMA. 2009;302(23):2531. doi:10.1001/jama.2009.1839

Although rheumatoid arthritis usually begins by attacking only one of the body's joints, it later spreads to nearly all of them. Now researchers from Germany have evidence that rheumatoid arthritis synovial fibroblasts (RASFs) in the fluid surrounding joints, cells that are already implicated as key players in destroying articular cartilage, can migrate and spread the disease (Lefèvre S et al. Nat Med. doi:10.1038/nm.2050 [published online November 8, 2009]).