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January 20, 2010

Long-term Mortality Associated With Acute Kidney Injury Requiring Dialysis

JAMA. 2010;303(3):229-230. doi:10.1001/jama.2009.1878

To the Editor: In a retrospective matched cohort study, Dr Wald and colleagues1 concluded that acute kidney injury (AKI) requiring dialysis was associated with an increased risk of end-stage renal disease but not all-cause mortality. This finding contradicts the conclusions of recent studies demonstrating a significant association between AKI and long-term mortality.2-4 The selection criteria for both the AKI exposure and control groups in their study might have contributed to this difference, rendering questionable the external validity of the study.