In Reply: Dr Anghelescu offers 2 possible explanations for why our clinical trial found no difference in depression in patients with CHD after 10 weeks of treatment with a standard antidepressant (sertraline) and either 2 g/d of omega-3 fatty acids or a placebo. First, he notes that our measures of depression severity include somatic symptoms that may be confounded with symptoms of heart disease and that this may have made it more difficult to observe a treatment effect. We chose the HAM-D and the BDI-II because they are widely used measures of depression severity in clinical trials and have been recommended for use in assessing depression in patients with heart disease.1
Carney RM, Freedland KE, Steinmeyer BC. Omega-3 Fatty Acids for CHD With Depression—Reply. JAMA. 2010;303(9):836. doi:10.1001/jama.2010.191
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