To the Editor: In their meta-analysis, Mr Fournier and colleagues1 drew the important conclusion that antidepressant medication, compared with placebo, is effective for very severely depressed patients but not for those who are less severely depressed. The authors stated that “evidence concerning the effects of [antidepressant medication] in patients with mild to moderate MDD [major depressive disorder] has been sparse.”
Elkin I. Depression Severity and Effect of Antidepressant Medications. JAMA. 2010;303(16):1596–1599. doi:10.1001/jama.2010.504
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: