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April 28, 2010

Depression Severity and Effect of Antidepressant Medications

JAMA. 2010;303(16):1596-1599. doi:10.1001/jama.2010.504

To the Editor: In their meta-analysis, Mr Fournier and colleagues1 drew the important conclusion that antidepressant medication, compared with placebo, is effective for very severely depressed patients but not for those who are less severely depressed. The authors stated that “evidence concerning the effects of [antidepressant medication] in patients with mild to moderate MDD [major depressive disorder] has been sparse.”