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May 26, 2010

Lactate Clearance and Central Venous Oxygen Saturation in Early Sepsis

JAMA. 2010;303(20):2031-2032. doi:10.1001/jama.2010.658

To the Editor: In their randomized controlled trial, Dr Jones and colleagues1 examined lactate clearance as an alternative to central venous oxygen saturation (ScvO2) for monitoring in the early phase of severe sepsis. Monitoring of ScvO2in the emergency department may be difficult to implement, and effective tools are needed to increase the overall adherence to Surviving Sepsis Campaign guidelines.2 However, the results of this study should be interpreted cautiously.