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Comment & Response
April 16, 2014

Dopamine vs Nesiritide for Acute Heart Failure With Renal Dysfunction

Author Affiliations
  • 1Cleveland Clinic Foundation, Cleveland, Ohio
JAMA. 2014;311(15):1565. doi:10.1001/jama.2014.2459

To the Editor Dr Chen and colleagues1 evaluated the role of low-dose dopamine and nesiritide as individual strategies in treating patients with acute decongested heart failure while attempting to preserve or improve renal function. The trial found no benefit from low-dose dopamine or nesiritide with standard diuretic therapy. Despite significant advances in understanding the pathophysiology of acute heart failure, contemporary therapies have failed to have an effect.2