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August 4, 2010

Antiepileptic Medications and the Risk of Suicide

JAMA. 2010;304(5):521-523. doi:10.1001/jama.2010.1067

To the Editor: Dr Patorno and colleagues1 studied antiepileptic drugs (AEDs) and the risk of suicide, reporting an increased risk of suicide attempts, completed suicide, or violent death in people taking gabapentin, lamotrigine, oxcarbazepine, tiagabine, and valproate, compared with topiramate. In extrapolating these findings to people with epilepsy, several points need to be borne in mind.