Author Affiliations: University of Iowa Carver College of Medicine and Core Investigator, Center for Research in Implementation of Innovative Strategies in Practice, Iowa City VA Medical Center, Iowa City (Dr Perencevich); Division of Infectious Diseases, University of Iowa Carver College of Medicine, Iowa City (Dr Diekema).
Staphylococcus aureus, unlike many virulent pathogens, is a common commensal asymptomatically colonizing the nares1 and other body sites in approximately 30% of healthy individuals. The remarkable success of S aureus as a human pathogen is due in large part to its ability to develop resistance to antimicrobial agents. Although it might appear that the increasing prevalence of resistant S aureus, particularly methicillin-resistant S aureus (MRSA), has been continuous and uninterrupted, understanding the evolution of S aureus resistance is helpful for interpretation of data on recent trends in invasive MRSA infection, such as those reported by Kallen and colleagues2 in this issue of JAMA.
Perencevich EN, Diekema DJ. Decline in Invasive MRSA Infection: Where to Go From Here? JAMA. 2010;304(6):687–689. doi:10.1001/jama.2010.1125
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