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August 11, 2010

Decline in Invasive MRSA Infection: Where to Go From Here?

Author Affiliations

Author Affiliations: University of Iowa Carver College of Medicine and Core Investigator, Center for Research in Implementation of Innovative Strategies in Practice, Iowa City VA Medical Center, Iowa City (Dr Perencevich); Division of Infectious Diseases, University of Iowa Carver College of Medicine, Iowa City (Dr Diekema).

JAMA. 2010;304(6):687-689. doi:10.1001/jama.2010.1125

Staphylococcus aureus, unlike many virulent pathogens, is a common commensal asymptomatically colonizing the nares1 and other body sites in approximately 30% of healthy individuals. The remarkable success of S aureus as a human pathogen is due in large part to its ability to develop resistance to antimicrobial agents. Although it might appear that the increasing prevalence of resistant S aureus, particularly methicillin-resistant S aureus (MRSA), has been continuous and uninterrupted, understanding the evolution of S aureus resistance is helpful for interpretation of data on recent trends in invasive MRSA infection, such as those reported by Kallen and colleagues2 in this issue of JAMA.