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Lab Reports
August 18, 2010

Obesity Clues From Marmots?

JAMA. 2010;304(7):733. doi:10.1001/jama.2010.1082

Yellow-bellied marmots never eat during hibernation, even when food is placed in front of them. But when scientists infused a molecule called 5-aminoimidazole-4-carboxamide 1 B-D-ribofuranoside (AICAR) into the hypothalamus of hibernating marmots, it stimulated them to feed (Florant GL et al. J Exp Biol. 2010;213[12]:2031-2037). The findings, by researchers from Colorado State University in Fort Collins, the University of Arizona–Phoenix, and other institutions, might help scientists better understand human obesity and eating habits.