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August 25, 2010

Genome-wide Association Study of Genetic Loci and Alzheimer Disease

JAMA. 2010;304(8):858. doi:10.1001/jama.2010.1172

To the Editor: The multistage genome-wide association study (GWAS) analysis of genetic loci associated with Alzheimer disease (AD) conducted by Dr Seshadri and colleagues1 presented evidence for association of 2 novel genetic loci with AD as well as confirmation for 2 previously reported associations (CLU and PICALM). rs744373 is located on chromosome 2, in a region that to our knowledge has not previously been associated with late-onset Alzheimer disease; there are no linkage entries for Chr 2 in http://www.alzgene.org or http://alzres.com.

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