To the Editor: The multistage genome-wide association study (GWAS) analysis of genetic loci associated with Alzheimer disease (AD) conducted by Dr Seshadri and colleagues1 presented evidence for association of 2 novel genetic loci with AD as well as confirmation for 2 previously reported associations (CLU and PICALM). rs744373 is located on chromosome 2, in a region that to our knowledge has not previously been associated with late-onset Alzheimer disease; there are no linkage entries for Chr 2 in http://www.alzgene.org or http://alzres.com.