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Comment & Response
May 7, 2014

Drugs for the Treatment of Obesity—Reply

Author Affiliations
  • 1Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland
  • 2Section on Growth and Obesity, National Institute of Child Health and Human Development, Bethesda, Maryland
JAMA. 2014;311(17):1807. doi:10.1001/jama.2014.2110

In Reply We agree with Drs Poulton and Nanan that the psychotropic actions of weight-loss medications are potentially of great importance, particularly given that most obesity medications approved or in development affect neurotransmitters that may have an effect on mood, cognition, or behavior. Some of these effects, such as negative mood or irritability, may be problematic, whereas others may potentially enhance ability to adhere to diet and exercise recommendations.

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