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Featured Clinical Reviews

October 20, 2010

Fish, Fish Oil, and Pregnancy

Author Affiliations

Author Affiliations: Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute (Dr Oken); and Division of Newborn Medicine, Children's Hospital Boston (Dr Belfort), Boston, Massachusetts.

JAMA. 2010;304(15):1717-1718. doi:10.1001/jama.2010.1541

Fish are a rich source of long-chain n-3 (omega-3) polyunsaturated fatty acids (PUFA), essential nutrients that have important structural and physiological roles in several body systems, including neurological, immune, and cardiovascular. Because humans cannot synthesize n-3 PUFA, these nutrients must be consumed in the diet. Conversion from the parent n-3 PUFA, α-linolenic acid, to the more biologically active long-chain n-3 PUFA, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), is inefficient and therefore consumption of some preformed long-chain n-3 PUFA is important for optimal health. In the United States and elsewhere, fish is the main dietary source of DHA and EPA.

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