In Reply: Our study and a companion study in colorectal surgery1 are 2 large phase 3 trials targeting separate common surgical procedures; both clearly failed to demonstrate efficacy of use of the gentamicin-collagen sponge. These are not the first trials to fail to show efficacy. Dr Corn cites 2 positive European trials.2,3 However, the study by Eklund et al was negative as indicated by its authors who wrote that their “ . . . prospective, randomized study showed no significant difference between infection rates in the two groups.”2
Bennett-Guerrero E, Mark DB, Corey GR. Treating Sternal Wound Infections After Cardiac Surgery With an Implantable Gentamicin-Collagen Sponge—Reply. JAMA. 2010;304(19):2123–2124. doi:10.1001/jama.2010.1614
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