To the Editor: In their Commentary, Drs Psaty and Prentice1 added to the available evidence that lack of blinding in randomized trials favors the intervention, even with studies that have what are considered hard end points. We agree about the importance of investigator blinding and would add a few observations and some cautions to their statements.
Strite SA, Stuart ME. Importance of Blinding in Randomized Trials. JAMA. 2010;304(19):2127–2128. doi:10.1001/jama.2010.1621
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