To the Editor: In their study, Dr Rodondi and colleagues1 addressed the issue of the relationship between subclinical hypothyroidism and coronary heart disease (CHD) or mortality. Previous large prospective cohort studies have provided conflicting results about this extensively studied association. In the study by Rodondi et al, an attempt to reduce the effects of several confounders (including age, sex, degree of thyroid stimulating hormone [TSH] elevation, and pre-existing cardiovascular disease) was performed.1 However, the finding of no association of risk with subclinical hypothyroidism for TSH concentration up to 10.0 mIU/L may be flawed because it did not provide information about the body mass index (BMI) of the patients diagnosed with subclinical hypothyroidism.
Mario Rotondi, Flavia Magri, Luca Chiovato. Risk of Coronary Heart Disease and Mortality for Adults With Subclinical Hypothyroidism. JAMA. 2010;304(22):2481–2482. doi:10.1001/jama.2010.1786