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March 4, 1998

Acetaminophen and WarfarinUndesirable Synergy

JAMA. 1998;279(9):702-703. doi:10.1001/jama.279.9.702

During the past 25 years, because of the important concern of bleeding associated with the use of aspirin via irreversible induced platelet dysfunction, the use of acetaminophen has steadily increased. Although acetaminophen is used primarily for its analgesic and antipyretic properties, this ubiquitous drug is taken by many for a wide range of nonspecific conditions as well. In the United States, acetaminophen is the most frequently ingested medication.1