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May 20, 1998

Reconsideration of Rifampin: A Unique Drug for a Unique Infection

Author Affiliations

From the Department of Internal Medicine, University of Utah Health Science Center, Salt Lake City.

JAMA. 1998;279(19):1575-1577. doi:10.1001/jama.279.19.1575

Implantation of foreign materials in the form of fixation devices and prosthetic joints has revolutionized the orthopedic surgical field in the last decades. These indisputable technological advances and sophisticated devices, although usually highly successful and devoid of complications, pose a challenging problem if they succumb to infection. Effective treatment of infections of implanted orthopedic devices has been extremely difficult regardless of repeated revision surgeries and prolonged courses of antimicrobials.