Fatigue is a prominent accompaniment of a wide range of disorders, including
acute or chronic infections, end-stage neoplasia, renal insufficiency, congestive
heart failure, and some psychiatric illnesses. It has been speculated that
the severe fatigue associated with neurocirculatory asthenia, termed irritable heart syndrome by Da Costa1
and soldier's heart by Lewis2
during World War I, were early descriptions of the symptoms of orthostatic
hypotension.3 The common experience of severe
fatigue after prolonged, exhausting physical labor or exercise and the muscular
symptoms that sometimes accompany chronic fatigue syndrome (CFS) have stimulated
research on the possible role of muscular disorders in its causation, but
with unconvincing results. And, of course, a viral origin has been commonly
considered to be a likely cause of chronic fatigue for many years.
Streeten DHP. The Nature of Chronic Fatigue. JAMA. 1998;280(12):1094–1095. doi:10.1001/jama.280.12.1094
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