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Medical News & Perspectives
January 13, 1999

New Method to Repair Faulty Genes Stirs Interest in Chimeraplasty Technique

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JAMA. 1999;281(2):119-121. doi:10.1001/jama.281.2.119

Scientists have developed a provocative new technique for correcting tiny but potentially devastating errors in mutant genes, an approach they hope will someday provide a strategy for treating at least some genetic disorders.

The approach, known as chimeraplasty or targeted gene correction, is still in its infancy and faces many technical challenges before it is clear whether the method can move from bench to bedside. Moreover, some skeptics say that a number of investigators have had difficulty getting the procedure to work and question whether the approach will be generally applicable to a variety of cell types.