Randomized trials evaluating drugs are frequently performed, both for purposes of initial regulatory approval and, after approval, to examine the utility of the drug in other clinical settings. No drug can get to market without being fully vetted. This is not the case for surgical procedures. Randomized trials evaluating surgical interventions are uncommon, even for some of the most commonly performed operations. In this issue of JAMA, 2 randomized clinical trials examine one of the most commonly performed general surgical operation—cholecystectomy for acute cholecystitis.
Solomkin JS. Clinical Trial Evidence to Advance the Science of Cholecystectomy. JAMA. 2014;312(2):135–136. doi:10.1001/jama.2014.7588
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