To the Editor The updated 2014 guidelines for the management of high BP in adults by the panel appointed to the JNC 81 did not consider issues relevant to sex differences in hypertensive health. Variables of age and race were addressed, but stratification by sex was omitted. Sex is a determinant of health outcomes, with differences in metabolism, hormonal milieu, pharmacodynamics, pathophysiology, and therapeutic considerations.
Klein WS, Merz CNB, Jenkins MR. Guidelines for Managing High Blood Pressure. JAMA. 2014;312(3):294–295. doi:10.1001/jama.2014.6593