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JAMA Clinical Challenge
July 23/30, 2014

Recurrent Erythema Multiforme

Author Affiliations
  • 1University of Texas Medical Branch, Galveston
  • 2Virginia Commonwealth University, Richmond
JAMA. 2014;312(4):426-427. doi:10.1001/jama.2014.3611

A 43-year-old African American woman with medical history of hepatitis C virus (HCV) infection was seen for a 2-year history of painful skin lesions on her legs and arms. Her lesions improved with prednisone but recurred when treatment was discontinued. No inciting factors were identified except a possible relation to her menstrual cycle. She also reported concurrent painful oral lesions. Erythematous, hyperpigmented, annular papules with dusky centers and bullae were observed on her arms and legs bilaterally (Figure, A, B, C). Oral lesions were also observed and consisted of erythematous, crusted papules with superficial ulceration, gingival hyperplasia, and superimposed thrush (Figure, D). The patient had no history of oral or genital herpes lesions. Results of herpes simplex virus (HSV) 1 and 2 IgG serologic testing were positive. Test results for pemphigus antibody panel, antinuclear antibodies, human immunodeficiency virus, and rapid plasma reagin were negative. Biopsy findings were consistent with erythema multiforme.