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Contempo 1999
March 10, 1999

New Horizons in the Treatment of Osteoarthritis of the Knee

Author Affiliations

Author Affiliation: Department of Orthopaedic Surgery, University of Minnesota, Minneapolis.


Edited by Thomas C. Jefferson, MD, JAMA Fishbein Fellow.

JAMA. 1999;281(10):876-878. doi:10.1001/jama.281.10.876

Osteoarthritis is not simply a degenerative disorder. Rather, it is a complex derangement of articular surfaces that involves the loss of normal collagen architecture followed by an attempt by chondrocytes to produce replacement cartilage. The replacement surface is less resistant to wear than the original. Over time, full-thickness cartilage loss may develop on the articular surfaces. Symptoms of osteoarthritis include joint pain, typically worse with use and eased with rest, and joint stiffness after nonuse. The pain can become persistent.