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Grand Rounds
March 10, 1999

Postexposure Chemoprophylaxis for Occupational Exposures to the Human Immunodeficiency Virus

Author Affiliations

Author Affiliation: Office of the Deputy Director for Clinical Care, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Md.


Grand Rounds at the Clinical Center of the National Institutes of Health Section Editors: John I. Gallin, MD, the Clinical Center of the National Institutes of Health, Bethesda, Md; David S. Cooper, MD, Contributing Editor, JAMA.

JAMA. 1999;281(10):931-936. doi:10.1001/jama.281.10.931

Postexposure chemoprophylaxis is now recommended for health care workers who experience certain kinds of occupational exposures to the human immunodeficiency virus (HIV) in the workplace. Substantial information has emerged that supports but does not prove the efficacy of antiretroviral agents in preventing HIV infection after occupational exposure. This article reviews the data that have accrued in the past 8 years that bear directly on this question and describes a systematic approach to the clinical management of health care workers occupationally exposed to HIV.