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Comment & Response
August 27, 2014

Bioprosthetic Valves for Transcatheter Aortic Valve Replacement

Author Affiliations
  • 1Department of Cardiothoracic Surgery, Houston Methodist DeBakey Heart and Vascular Center, Houston, Texas
JAMA. 2014;312(8):844-845. doi:10.1001/jama.2014.8364

To the Editor The CHOICE trial1 is the first randomized trial comparing balloon-expandable and self-expandable valves for TAVR. This trial used the VARC definition of device success as a composite primary end point. It found a higher device success with the balloon-expandable valve, driven largely by a lower frequency of aortic regurgitation. There are several serious flaws in the trial design that call these conclusions into question.