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Lab Reports
September 3, 2014

Growth Factor Injections Reverse Type 2 Diabetes in Mice

JAMA. 2014;312(9):882. doi:10.1001/jama.2014.11280

One injection of recombinant fibroblast growth factor 1 (rFGF1) restored healthy blood glucose levels in obese diabetic mice for more than 2 days in a recent study (Suh JM et al. Nature. doi:10.1038/nature13540 [published online July 16, 2014]).

Previous research has shown that FGF1 injections have no effect on healthy mice, but in this latest work, a series of injections with rFGF1 increased insulin-dependent glucose uptake in skeletal muscle and suppressed liver production of glucose to achieve whole-body insulin sensitization.