Atrial fibrillation (AF) occurs commonly, especially in the elderly, and is associated with increased mortality and a variety of serious conditions such as heart failure, stroke, and myocardial infarction (MI). In a recent article in JAMA Internal Medicine, Soliman et al1 analyzed data from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study to evaluate whether AF was associated with increased risk for MI. After the researchers excluded patients with established coronary heart disease at baseline, 1631 patients with and 22 297 without AF were included in the analysis. The authors also examined subgroups of patients taking warfarin and aspirin at baseline, but data on serial anticoagulation use and international normalized ratio (INR) values were not available.
Eric N. Prystowsky, Edward T. Fry. Atrial Fibrillation and Incident Myocardial Infarction. JAMA. 2014;312(10):1049–1050. doi:10.1001/jama.2014.5742