Author Affiliations: Department of Medical Microbiology and Immunology, Ohio State University Medical Center, Columbus (Dr Glaser); Pathology Department, University of Pittsburgh Medical Center, Clinical Immunopathology-CLSI, Pittsburgh, Pa (Dr Rabin); Department of Medicine, University of California, San Francisco (Dr Chesney); Department of Psychology, Carnegie-Mellon University, Pittsburgh (Dr Cohen); and Department of Neurosciences, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, East Orange (Dr Natelson).
Edited by Thomas C. Jefferson, MD, JAMA Fishbein
There is now significant
literature showing that psychological stress can down-regulate various
aspects of the cellular immune response. It is also established that
communication between the central nervous system and the immune system
occurs through bidirectional signals linking the nervous, endocrine,
and immune systems. Psychological stressors affect the immune system by
disrupting these networks. In this overview, we discuss the
implications of psychological stress-associated immune modulation and
risk for infectious disease.
Glaser R, Rabin B, Chesney M, Cohen S, Natelson B. Stress-Induced Immunomodulation: Implications for Infectious Diseases? JAMA. 1999;281(24):2268–2270. doi:10.1001/jama.281.24.2268
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