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Contempo 1999
June 23/30, 1999

Stress-Induced Immunomodulation: Implications for Infectious Diseases?

Author Affiliations

Author Affiliations: Department of Medical Microbiology and Immunology, Ohio State University Medical Center, Columbus (Dr Glaser); Pathology Department, University of Pittsburgh Medical Center, Clinical Immunopathology-CLSI, Pittsburgh, Pa (Dr Rabin); Department of Medicine, University of California, San Francisco (Dr Chesney); Department of Psychology, Carnegie-Mellon University, Pittsburgh (Dr Cohen); and Department of Neurosciences, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, East Orange (Dr Natelson).


Edited by Thomas C. Jefferson, MD, JAMA Fishbein Fellow.

JAMA. 1999;281(24):2268-2270. doi:10.1001/jama.281.24.2268

There is now significant literature showing that psychological stress can down-regulate various aspects of the cellular immune response. It is also established that communication between the central nervous system and the immune system occurs through bidirectional signals linking the nervous, endocrine, and immune systems. Psychological stressors affect the immune system by disrupting these networks. In this overview, we discuss the implications of psychological stress-associated immune modulation and risk for infectious disease.