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Comment & Response
September 17, 2014

Recurrence Rates in Autism Spectrum Disorders—Reply

Author Affiliations
  • 1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
  • 2Department of Psychiatry, Ichan School of Medicine at Mount Sinai, New York, New York
JAMA. 2014;312(11):1155. doi:10.1001/jama.2014.9847

In Reply We share Dr Constantino’s interest in determining if there are differences in the etiology of ASD between males and females. We did not compare the heritability of ASD between males and females in the study for 2 reasons.

First, even a large population-based study such as ours has limited power to detect statistically significant sex differences in heritability. Second, we addressed the question of sex effects in our recurrence risk analysis. We did not observe important or statistically significant differences in recurrence risk in siblings and cousins for the different sibling and cousin sex combinations.