An analysis of specimens from patients with Ebola virus disease during the 2000-2001 outbreak in Uganda’s Gulu District has shown that pediatric patients who survived had higher levels of certain biomarkers than children and adolescents who died.
Included in the analysis were specimens from 55 pediatric patients and 50 adult patients, all with laboratory-confirmed infection. The results showed that pediatric patients who survived had higher levels of a particular protein—a chemokine called regulated on activation, normal T-cell expressed and secreted (RANTES), also known as CCL5—than those who died. The surviving pediatric patients also had lower levels of plasminogen activator inhibitor 1, soluble intracellular adhesion molecule, and soluble vascular cell adhesion molecule than did those who died (McElroy AK et al. Emerg Infect Dis. doi: 10.3201/eid2010.140430 [published online July 29, 2014]).
Pediatric Ebola Survivors. JAMA. 2014;312(11):1089. doi:10.1001/jama.2014.11157
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