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Clinical Trials Update
September 24, 2014

Suicide Runs in Families With ADHD

JAMA. 2014;312(12):1184. doi:10.1001/jama.2014.13083

Shared genetic factors may partly explain the increased risk of suicide among persons with attention-deficit/hyperactivity disorder (ADHD), found a longitudinal study of 51 707 Swedish patients with ADHD and their families (Ljung T et al. JAMA Psychiatry. 2014;71[8]:958-964). Heritable traits such as impulsivity play a large role in both ADHD and suicidal behavior and may explain the pattern of familial susceptibility to both, the authors said.

Compared with matched control participants, individuals with ADHD had increased risks of attempted and completed suicide, even after adjusting for comorbid psychiatric disorders (odds ratio [OR], 3.62 [95% CI, 3.29-3.98] and OR, 5.91 [95% CI, 2.45-14.27], respectively). First-degree relatives also had a higher risk of attempted suicide (OR, 2.42 among parents and OR, 2.49 among full siblings). The risk of completed suicide was also elevated among first-degree relatives.

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