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Comment & Response
October 8, 2014

Antipsychotic Medications for Schizophrenia

Author Affiliations
  • 1Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan
JAMA. 2014;312(14):1468-1469. doi:10.1001/jama.2014.10103

To the Editor Pharmacological treatment of schizophrenia in the real world is frequently challenging. Dr McEvoy and colleagues1 compared paliperidone palmitate with haloperidol decanoate in patients with schizophrenia deemed at high risk of destabilization.

McEvoy et al1 found that paliperidone palmitate was not significantly different from haloperidol decanoate in the rate of efficacy failure (33.8% vs 32.4%, respectively), with some differences in tolerability. Several issues need to be taken into account in interpreting their clinically relevant findings.