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Comment & Response
October 8, 2014

Antipsychotic Medications for Schizophrenia—Reply

Author Affiliations
  • 1Columbia University College of Physicians and Surgeons, New York, New York
  • 2Georgia Regents University, Augusta, Georgia
  • 3University of North Carolina, Chapel Hill
JAMA. 2014;312(14):1469. doi:10.1001/jama.2014.10112

In Reply Dr Fleischhacker suggests that high dropout rates limit the generalizability of our findings. This effectiveness study included participants that clinicians selected as candidates for long-acting injectable antipsychotic medications (ie, they were expected to benefit from depot treatment because they were at risk of poor outcomes due to a history of poor adherence or substance abuse). Thus the findings should be generalizable to typical patients for whom treatment with long-acting injectable antipsychotics is considered.