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Comment & Response
October 15, 2014

Benefits and Risks Associated With Thrombolysis for Pulmonary Embolism—Reply

Author Affiliations
  • 1Division of Cardiology, St Luke’s-Roosevelt Hospital, New York, New York
  • 2Cardiovascular Medicine Division, University of Pennsylvania Perelman School of Medicine, Philadelphia
JAMA. 2014;312(15):1589-1590. doi:10.1001/jama.2014.10789

In Reply Dr Bradford and colleagues suggest that the Peto method of determination of pooled ORs may be flawed because the event rates for mortality in pulmonary embolism trials were approximately 3%. However, at event rates less than 5%, the Peto method provides the least biased estimates of treatment effect when compared with the corrected Mantel-Haenszel, DerSimonian-Laird, and inverse-variance ORs.1