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In Reply Dr Bradford and colleagues suggest that the Peto method of determination of pooled ORs may be flawed because the event rates for mortality in pulmonary embolism trials were approximately 3%. However, at event rates less than 5%, the Peto method provides the least biased estimates of treatment effect when compared with the corrected Mantel-Haenszel, DerSimonian-Laird, and inverse-variance ORs.1
Chatterjee S, Giri J. Benefits and Risks Associated With Thrombolysis for Pulmonary Embolism—Reply. JAMA. 2014;312(15):1589–1590. doi:10.1001/jama.2014.10789
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