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Comment & Response
November 12, 2014

Erythropoietin for Traumatic Brain Injury—Reply

Author Affiliations
  • 1Department of Neurosurgery, Baylor College of Medicine, Houston, Texas
  • 2University of Texas School of Public Health, Houston
JAMA. 2014;312(18):1929. doi:10.1001/jama.2014.12744

In Reply Most of the evidence to date supporting neuroprotection after traumatic brain injury with erythropoietin administration comes from experimental studies. Two case-matched studies in patients with traumatic brain injury and large clinical trials in general trauma patients have found improvements in mortality with erythropoietin treatment.1-3 For patients with traumatic brain injury, however, recovery of neurological function long-term is more important than simple survival and none of these previous studies have adequately addressed long-term outcome.

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