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JAMA 100 Years Ago
September 27, 2000


Author Affiliations

JAMA 100 Years Ago Section Editor: Jennifer Reiling, Editorial Assistant.

JAMA. 2000;284(12):1490. doi:10.1001/jama.284.12.1490


The origin of organo-therapeutics dates from Brown-Séquard's experiments in 1889 and the doctrine of internal secretion formulated by him that "all glands and all tissues have an internal secretion and all injected subcutaneously have a tonic effect" is taken as the text of this article. During the past five or six years Easterbrook has administered in various forms of insanity extracts of the following animal organs: The thyroid gland, the parathyroid bodies, the thymus, the pituitary body, the brain, the choroid plexus, the spleen, the suprarenal bodies, the testes, the ovaries, the uterus, and the mammæ. With the exception of the thyroid, none of these have been very generally employed by alienists, and parathyroid extract so far as he knows has not been employed before at all.