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Featured Clinical Reviews

November 19, 2014

Population and Personalized Medicine in the Modern Era

Author Affiliations
  • 1TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts
  • 2American Heart Association, Dallas, Texas
JAMA. 2014;312(19):1969-1970. doi:10.1001/jama.2014.15224

Classic health care research has centered on studying a group of individuals and then extrapolating the findings to the general population. In this context, evaluating the association between nonrandomized exposures and clinical outcomes can yield interesting, hypothesis-generating correlations, but assembling evidence to suggest a causal relationship has focused on testing the relationship between randomized exposures and clinical outcomes1 (Figure).

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